July 2023 Alzheimer’sNews

Exercising Regularly May Help Prevent Alzheimer’s

According to new research, people with leaner muscles are less likely to develop the disease. Lead author Dr. Iyas Daghlas, of the University of California, San Francisco said: “Based on human genetics data, individuals randomized to lifelong lean muscle mass had a 12 percent lower risk of Alzheimer’s disease and scored higher for cognitive performance.”

The U.S. team analyzed over a million volunteers, including 450,243 from the UK Biobank, which contains information on their DNA. They used a technique known as “Mendelian randomization” – variants linked to specific risk factors. Some of us are naturally programed to have lean muscles. They can also be built by combining a healthy diet with resistance training- such as lifting weights. With no cure in sight there’s increasing focus on protective lifestyles. Dr. Daghlas said: “Despite the steady increase in the prevalence, no effective treatments for this devastating disease exist. Prevention of Alzheimer’s through identification of modifiable risk factors is thus a key public health aim.”

Piling on the pound’s fuels inflammation. It’s also been linked to increasing neuron-destroying rogue proteins called amyloid beta. Lower levels of lean muscle have also been associated with dementia. The study in “BMJ Medicine” sheds light on the link. Those with high amounts had a reduction in Alzheimer’s risk. Results were “statistically robust” after taking account of age, sex and ancestry. Dr. Daghlas said: “These analyses provide new evidence supporting a cause-and -effect relation between lean mass and risk of Alzheimer’s disease.

They also refute a large effect of fat mass on the risk of Alzheimer’s disease and highlight the importance of distinguishing between lean mass and fat mass when investigating the effect of adiposity measures on health outcomes.” Identifying biological mechanisms behind the phenomenon would open the door to developing drugs that target them. Dr. Daghlas said: “Several mendelian randomization analyses have identified the effects of cardiometabolic risk factors on the risk of Alzheimer’s disease, which could be further investigated as potential mediators of the effect of lean mass.” The effect could also be mediated by new mechanisms, including circulating myokines – proteins released during strenuous exercise. Dr. Daghlas said: “Potentially relevant secreted myokines include irisin, brain-derived neurotrophic factor 5, and cathepsin B.

Identification of the key causal pathways might lead to the development of treatments that harness and potentiate the neuroprotective effects of lean Mass”. He added: “Our findings need to be replicated with independent lines of complementary evidence before informing public health or clinical practice. Also, more work is needed to determine the cut-off values for age and degree of pathology of Alzheimer’s disease after which modifications of lean mass might no longer reduce the risk.” Nor is it clear whether increasing lean mass could reverse the pathology of Alzheimer’s disease in patients with preclinical disease or mild cognitive impairment. But if future studies back the findings “public health efforts to shift the population distribution of lean mass, potentially through campaigns to promote exercise and physical activity, might reduce the population burden of Alzheimer’s disease”, said Dr. Daghlas.

You can learn more by going to www. alz.org/help-support/resources or the Alzheimer’s Helpline which is accessible 24/7 via 800-272-3900 and staffed by master’s level clinicians to assist with crisis situations, decision making, and disease information. You can find virtual dementia caregiver resources online at alz.org/covid19help. Tools and support are also available in Spanish.
Want to learn more about the Alzheimer’s Association and what they do here in St. Louis? Visit alz.org and/or contact PUCC’s Faith Outreach Ambassador with the Alzheimer’s Association, Joyce Ruiz at joyceruiz7@gmail.com